Early Christian relic veneration grows directly out of the cult of the martyrs. Christians gathered annually at the tombs of those executed in the persecutions — Polycarp in Smyrna in 155, Cyprian in Carthage in 258, the Roman martyrs in the catacombs — to celebrate the eucharist on the anniversary of the death. The tomb became an altar. From the fourth century onward, with martyrdom no longer the path of most Christians, the relics themselves are translated — moved from one church to another — and the network of pilgrimage routes follows. Saint Nicholas's remains are taken from Myra to Bari by Italian sailors in 1087; the reputed bones of the Three Magi are taken from Milan to Cologne by Frederick Barbarossa's chancellor in 1164; the body of Saint Martin of Tours, the patron of Gaul, anchored one of the earliest mass pilgrimages in Latin Christendom. Conques, Vézelay, Saint-Maximin-la-Sainte-Baume, Mont-Saint-Michel, Loreto — every great medieval pilgrimage site is a relic site.
The Buddhist trajectory begins with the funeral of the Buddha at Kushinagar around 483 BC. The Mahāparinibbāna Sutta describes the division of the cremated remains among eight kingdoms, each of which raised a stupa over its portion. Two centuries later, the emperor Ashoka — by his own inscriptions a remorseful convert after the conquest of Kalinga — is said to have opened seven of the eight original stupas and redistributed the relics into 84,000 portions across his empire and beyond. The Tooth Relic, said to have been rescued from the cremation pyre, was brought to Sri Lanka in the fourth century and became inseparable from Sinhalese kingship; the king who held the Tooth held the right to rule. The great Mahabodhi Temple at Bodh Gaya, marking the place of the awakening, was built in its present form in the fifth or sixth century AD and has been a pilgrimage site for at least two millennia.
Shiʿa Imam shrines are simultaneously tombs and sites of foundational mourning. The killing of Hussein and his companions at Karbala on the tenth of Muḥarram, 680 AD, is the central event of Shiʿa history; the Arbaʿīn pilgrimage that marks the fortieth day after his death now draws between fifteen and twenty-five million pilgrims annually to Karbala, on foot, in what has become one of the largest gatherings of human beings anywhere in the world. Najaf, where Ali is buried, is the seat of the marjaʿīya, the senior clerical authority of Twelver Shiʿism. Mashhad, with the shrine of the Imam Reza, draws more than twenty million pilgrims a year. The continuity is not antiquarian. It is among the most concentrated and continuously practiced forms of pilgrimage on earth.